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A two-color interacting random balls model for co-localization analysis of proteins


A two-color interacting random balls model for co-localization analysis of proteins
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A model of two-type (or two-color) interacting random balls is introduced. Each colored random set is a union of random balls and the interaction relies on the volume of the intersection between the two random sets. This model is motivated by the detection and quantification of co-localization between two proteins. Simulation and inference are discussed. Since all individual balls cannot been identified, e.g. a ball may contain another one, standard methods of inference as likelihood or pseudolikelihood are not available and we apply the Takacs-Fiksel method with a specific choice of test functions.
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A two-color interacting random balls model for co-localization analysis of proteins
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